发明名称 |
Liposome composition for delivery of nucleic acid |
摘要 |
A liposome composition for delivery of a nucleic acid in vivo or ex vivo is described. The liposomes in the composition are comprised of (i) a lipid that is neutral in charge at physiologic pH and positively charged at pH values less than physiologic pH and (ii) a lipid joined to a hydrophilic polymer by a dithiobenzyl linkage. The liposomes are associated with a nucleic acid for delivery to a cell.
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申请公布号 |
US7112337(B2) |
申请公布日期 |
2006.09.26 |
申请号 |
US20010020671 |
申请日期 |
2001.12.12 |
申请人 |
ALZA CORPORATION |
发明人 |
HUANG SHI-KUN;ZALIPSKY SAMUEL;ZHANG WEI-MING |
分类号 |
A61K9/127;A61K31/7088;A61K47/14;A61K47/30;A61K47/42;A61K47/48;A61K48/00;A61P35/00;A61P43/00;C07D233/54;C12N15/88 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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