发明名称 |
Synthesis procedure for imidazolyl carbinol derivatives such as biphenylimidazolyl-(1)-phenylmethane |
摘要 |
A synthesis procedure for the manufacture of byphenylimidazolyl-(1)-phenylmethane involves the reduction of 4-phenyl-benzophenone and subsequent reaction of biphenyl-phenyl-carbinol with imidazole. In a preferred form, there are two synthesis steps, the first step being the reduction of 4-phenyl-benzophenone to biphenyl-phenyl-carbinol being with sodium borohydride in the presence of alumina, and the second step being the reaction between biphenyl-phenyl-carbinol and imidazole assisted by microwaves, in the absence of any organic or inorganic solvents, obtaining a yield between 70 to 74% of pure product in a total reaction time of no more than three hours.
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申请公布号 |
US7112681(B2) |
申请公布日期 |
2006.09.26 |
申请号 |
US20040805215 |
申请日期 |
2004.03.22 |
申请人 |
MANUFACTURAS HUMBERTO BUKELE E HIJOS, S.A DE C.V |
发明人 |
HANDAL VEGA ERLINDA;ARIAS CARMEN ELENA;GARCIA JORGE MANUEL COLLAZO |
分类号 |
C07D233/58;C07D233/54;C07D233/62;C07D521/00 |
主分类号 |
C07D233/58 |
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