| 发明名称 |
Non-invasive diagnostic imaging technology for mitochondria dysfunction using radiolabeled lipophilic salts |
| 摘要 |
The invention provides a series of lipophilic phosphonium cations (PhCs) labeled with <SUP>18</SUP>F for non-invasive assessment of DeltaPsim, lipophilic ammonium cation analogs of the PhCs, and methods of using same for imaging and detection of mitochondrial-related pathologies in patients using PET or SPECT.
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| 申请公布号 |
US7112318(B2) |
申请公布日期 |
2006.09.26 |
| 申请号 |
US20030360566 |
申请日期 |
2003.02.06 |
| 申请人 |
THE JOHNS HOPKINS UNIVERSITY |
发明人 |
MADAR IGAL;RAVERT HAYDEN T.;DANNALS ROBERT FRANCIS;SCHEFFEL URSULA A.;FROST JAMES J. |
| 分类号 |
A61K51/00;A61K49/00;A61K51/04;A61M36/14;A61P35/00;C07B59/00;C07C211/63;C07C211/64;C07F9/54 |
主分类号 |
A61K51/00 |
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