Respiratory syncytial virus replication inhibitors

摘要

This invention concerns compounds of formula prodrugs, N-oxides, addition salts, quaternary amines, metal complexes or stereochemically isomeric forms thereof wherein -a<1>=a<2>-a<3>=a<4>- is a radical of formula - CH=CH-CH=CH-, -N=CH-CH=CH-, -CH=N-CH=CH-, -CH=CH-N=CH-, -CH=CH-CH=N- wherein each hydrogen atom may optionally be substituted; Q is a radical of formula wherein Alk is C1-6alkanediyl; Y<1> is a bivalent radical of formula -NR<2>- or -CH(NR<2>R<4>)-; X<1> is NR<4>, S, S(=O), S(=O)2, O, CH2, C(=O), CH(=CH2), CH(OH), CH(CH3), CH(OCH3), CH(SCH3), CH(NR<5a>R<5b>), CH2-NR<4> or NR<4>-CH2; X<2> is a direct bond, CH2, C(=O), NR<4>, C1-4alkyl-NR<4>, NR<4>-C1-4alkyl; t is 2 to 5; u is 1 to 5; v is 2 or 3; and whereby each hydrogen in Alk and in (b-3), (b-4), (b-5), (b-6), (b-7) and (b-8), may optionally be replaced by R<3>; provided that when R<3> is hydroxy or C1-6alkyloxy, then R<3> can not replace a hydrogen atom in the alpha position relative to a nitrogen atom; G is a direct bond or C1-10alkanediyl; R<1> is an optionally substituted monocyclic heterocycle; R<2> is hydrogen, formyl, pyrrolidinyl, piperidinyl, homoiperidinyl, C3- 7cycloalkyl or C1-10alkyl substituted with N(R<6>)2 and optionally with another substituent; R<3> is hydrogen, hydroxy, C1-6alkyl, C1-6alkyloxy, arylC1-6alkyl or arylC1- 6alkyloxy; R<4> is hydrogen, C1-6alkyl or arylC1-6alkyl; R<5a>, R<5b>, R<5c> and R<5d> each independently are hydrogen or C1-6alkyl; or R<5a> and R<5b>, or R<5c> and R<5d> taken together from a bivalent radical of formula -(CH2)s- wherein s is 4 or 5; R<6> is hydrogen, C1- 4alkyl, formyl, hydroxyC1-6alkyl, C1-6alkylcarbonyl or C1-alkyloxyarbonyl; aryl is optionally substituted phenyl; and their use for the manufacture of a medicament for the treatment of viral infections, in particular RSV infections.