摘要 |
The invention concerns quinazoline derivatives of the formula: (I); wherein X<SUP>1</SUP>, Q<SUP>1</SUP>, Z, R<SUP>1</SUP>, R<SUP>2</SUP>, Y, a and m are as defined in the description, which are erbB tyrosine kinase inhibitors, particularly EGFR tyrosine kinase inhibitors. Also claimed are processes for their preparation; pharmaceutical compositions containing them; and their use as therapeutic agents in the treatment of erbB tyrosine kinase mediated diseases such as cancer.
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