BISHETEROCYCLE TANDEM COMPOUNDS USEFUL AS ANTIVIRAL AGENTS, THE USES THEREOF AND THE COMPOSITIONS COMPRISING SUCH COMPOUNDS

摘要

The present invention provides bisheterocycle tandem small molecule compounds of formula P1-P2, the uses thereof and the compositions comprising such compounds, wherein P1 and P2 each independently represent an unsaturated 5-member heterocyclic ring having one or two heteroatoms. Such compounds can effectively inhibit the replication of influenza virus, the DNA replication of hepatitis B virus (HBV) , and the synthesis of HBs Ag and HBe Ag. These compounds can be used in the preparation of a medicament for the treatment of viral diseases, and may overcome the disadvantages of the known nucleosides such as cytotoxicity, the occurrence of drug-resistant virus variants induced by long-term therapy, and the requirement of other drugs having different structure. The structures of compounds according to the invention are more simple and easy to be prepared.