发明名称 |
MACROMOLECULES COMPRISING A THIOETHER CROSS-LINK |
摘要 |
The present invention provides macromolecules comprising at least one thioether cross-link. A thioether cross-link comprising a single thioether bond between two residues of a macromolecule. The macromolecules of the invention can display enhanced stability, pharmaceutical properties and functional properties. In particular, the invention provides an isolated antibodies comprising at least one thioether cross-link that specifically bind to particular antigens. The present invention also provides a composition comprising a macromolecule substantially free of a denaturing reagent, wherein the macromolecule comprises at least one thioether cross-link. In addition, the present invention provides a method for producing the macromolecules and compositions of the invention. |
申请公布号 |
CA2600844(A1) |
申请公布日期 |
2006.09.21 |
申请号 |
CA20062600844 |
申请日期 |
2006.03.14 |
申请人 |
MEDIMMUNE, INC. |
发明人 |
WEI, ZIPING;SCHENERMAN, MARK;TOUS, GUILLERMO I. |
分类号 |
C07K1/00;C07K1/10;C07K16/00;C12P21/08 |
主分类号 |
C07K1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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