摘要 |
Disclosed are compositions and methods for Here, it is shown that vaccination with peptide-coated dendritic cells (DC) generated antigen-(Ag) specific CD8<SUP>+</SUP> T-cells with the phenotype and function of memory T-cells as early as 4-6 days after immunization. These memory-like CD8<SUP>+</SUP> T-cells underwent vigorous secondary expansion, resulting in rapid generation of elevated secondary memory CD8<SUP>+</SUP> T-cell numbers and increased protective immunity, in response to a variety of booster immunizations. However, concurrent inflammation prevented the rapid generation of memory T-cells by DC immunization. Thus, DC vaccination, in the absence of overt inflammation, accelerated memory cell generation and dramatically reduced the interval required for booster amplification of memory CD8<SUP>+</SUP> T-cell numbers. |
申请人 |
UNIVERSITY OF IOWA RESEARCH FOUNDATION;HARTY, JOHN;BADOVINAC, VLADIMIR, P.;MESSINGHAM, KELLY, A.N. |
发明人 |
HARTY, JOHN;BADOVINAC, VLADIMIR, P.;MESSINGHAM, KELLY, A.N. |