摘要 |
Post-translational O-sulfonation of a serine or threonine residue of proteins is detected, optionally comparatively, wherein the detected O-sulfonation is detected under a first physiological condition, and is compared with a control O-sulfonation detected under a second physiological condition, and a difference between the detected and control O-sulfonation indicates a difference between the first and second physiological conditions. Predetermined changes in physiological conditions are used to infer specific changes in O-sulfonation. Proteins are modified by introducing a predetermined change in O-sulfonation at a serine or threonine residue of the protein, and optionally, detecting a resultant change in O-sulfonation. These methods include introducing or increasing O-sulfonation, eliminating or reducing O-sulfonation; and derivatizing or substituting O-sulfonation. |
申请人 |
REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE;MANN INSTITUTE OF SCIENCE YEDA RESEARCH AND DEVELOPMENT CO. LTD. AT THE WEIZ |
发明人 |
BURLINGAME, ALMA, L.;MEDZIRHADSZKY, KATALIN, F.;DARULA, ZSUZSANNA;CHALKLEY, ROBERT;TYSON, DARREN;PERLSON, ERAN;FAINZILBER, MICHAEL;BRADSHAW, RALPH |