发明名称 |
Means and methods for the recruitment and identification of stem cells |
摘要 |
Described are methods of modulating stem/progenitor cell recruitment involving molecules that agonize the formation of plasmin stimulating the recruitment of stem/progenitor cells, including hematopoietic and endothelial precursor cells. Conversely, antagonists of plasmin can inhibit recruitment of the stem cells. In addition, the identification of the uPA receptor (uPAR) as a retention signal for stem cells in their niche suggests a novel method for increased engraftment and isolation of multipotent stem cells.
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申请公布号 |
US2006210532(A1) |
申请公布日期 |
2006.09.21 |
申请号 |
US20060390931 |
申请日期 |
2006.03.28 |
申请人 |
D. COLLEN RESEARCH FOUNDATION VZW |
发明人 |
CARMELIET PETER;TJWA MARC |
分类号 |
A61K38/19;A61K31/203;A61K31/4015;A61K31/60;A61K38/16;A61K38/17;A61K38/18;A61K38/43;A61K38/46;A61K38/48;A61K38/49;A61K38/51;A61K38/55;A61K39/00;A61K39/395 |
主分类号 |
A61K38/19 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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