| 摘要 |
The present invention provides methods to reduce or eliminate alpha-mannosidase resistant glycans on glycoproteins in yeast. The reduction or elimination of alpha-mannosidase resistant glycans on glycoproteins results from the disruption of the newly isolated P. pastoris AMR2 gene encoding beta1,2-mannosyltransferase. The present invention also discloses novel genes, polypeptides, antibodies, vectors and host cells relating to alpha-mannosidase resistance on glycans.
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