Process for the preparation of angiotensin receptor blockers and intermediates thereof

摘要

A process for the preparation of a biphenyl-containing compound of general formula I: wherein R¹ is a C_3-6 carbonyl containing compound; R² is a substituted or unsubstituted, straight or branched C_3-6 alkyl group, or R¹ and R² together with the nitrogen atom to which they are bonded are joined together to form a substituted heterocyclic group selected from the group consisting of substituted or unsubstituted imidazoles, substituted or unsubstituted benzimidazoles and substituted or unsubstituted 1,3-diazaspiro[4,4]non-1-en-4-one; and R³ is a carboxylic acid ester, cyano, a substituted or unsubstituted 1H-tetrazolyl group or a substituted or unsubstituted group which may be converted in vivo into a carboxy group is provided, the process comprising reacting a compound of general formula II: wherein R¹ and R² have the aforestated meanings with a compound of general formula III: wherein Z is a leaving group and R³ has the aforestated meaning in a biphasic solvent system in the presence of a phase transfer catalyst.