METHOD AND SYSTEM FOR MODULATING ENERGY EXPENDITURE AND NEUROTROPHIC FACTORS

摘要

A method system for modulating the energy expenditure and/or the expressed brain-derived neurotrophic factor (BDNF) in the brain of an individual is performed by a system that includes a control device that generates a stimulation pattern from a predetermined set of stimulation parameters, and that converts the stimulation pattern into a stimulation signal. A stimulati on signal delivery mechanism, configured for implantation into a selected part of the brain, receives the stimulation signal from the control device and delivers the signal to the selected part of the brain. The stimulation signa l may be an electrical signal delivered by a brain-implantable electrode, or a chemical signal in the form of a drug dosage regimen delivered by an implantable micropump under the control of the control device. Modulation of the energy expenditure and/or BDNF is achieved by the stimulation of the hypothalamus, either directly or indirectly, by the stimulation signal.