发明名称 |
METHOD FOR PREPARING A USEFUL SECONDARY METABOLITE BY EFFECTIVE ELIMINATION OF BIOLOGICAL BY-PRODUCTS |
摘要 |
<p>The present invention relates to a method that improves productivity of a useful secondary metabolite by eliminating biological by-products effectively during the culture of a useful secondary metabolite-producing microorganism, and more particularly, in order to efficiently eliminate biological by-products formed during the culture of Soragium cellulosum, the present invention relates to a method for producing epothilones comprising that a cation exchange resin is added to said culture medium or said culture broth is recirculated through a column charged with a cation exchagen resin. According to the present invention, the effective elimination of by-products formed during the culture of Sorangium celluosumenhances growth rate of the microorganism as well as dramatically improves productivity of epothilones, a useful secondary metabolite.</p> |
申请公布号 |
WO2006098585(A1) |
申请公布日期 |
2006.09.21 |
申请号 |
WO2006KR00926 |
申请日期 |
2006.03.15 |
申请人 |
BORATION SUNGKYUNKWAN UNIVERSITY FOUNDATION CORPORATE COLLA;HUONS CO., LTD.;SIM, SANG-JUN;PARK, SANG-WOO;YOON, SUNG-TAE |
发明人 |
SIM, SANG-JUN;PARK, SANG-WOO;YOON, SUNG-TAE |
分类号 |
C12N1/20;C12P1/04;C12P17/18 |
主分类号 |
C12N1/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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