| 摘要 |
<p>The invention provides extraction columns for the purification of an analyte (e.g., a biological macromolecule, such as a peptide, protein or nucleic acid) from a sample solution, as well as methods for making and using such columns. The columns typically include a bed of extraction media positioned in the column between two frits. In some embodiments, the invention provides columns having low bed volumes. In some embodiments, the invention provides columns characterized by low backpressure. In some embodiments, the invention provides methods characterized by the elution of analyte in a small volume of liquid.</p> |
