| 摘要 |
The present invention relates to methods of preparing a stereoisomerically enriched compound of formula (I), wherein R6 is hydrogen, comprising treating a compound of formula (I), wherein R6 is chosen from C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkenyl, -(CR7R8)t(C6-C14 aryl), and - (CR7R8)t(4-10 membered heterocyclic), and wherein said C6-C14 aryl and 4-10 membered heterocyclic are optionally substituted with at least one substituent chosen from halo, C1-C10 alkyl, -OR7, and -N(R7R 8), with a biocatalyst in an aqueous solution, an organic solvent, or a mixture of organic and aqueous solvents wherein at least one stereoisomer is selectively hydrolyzed.
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