FABRICATION METHOD OF CARBOHYDRATE CHIPS USING UNMODIFIED CARBOHYDRATE, AND CARBOHYDRATE CHIPS FABRICATED BY THE METHOD

摘要

A method for fabricating carbohydrate chip is provided to prepare the carbohydrate chip capable of selectively and covalently fixing various un-modified carbohydrates regardless of sizes. The method comprises the steps of: (a) preparing a chip substrate including a solid substrate such as polymer, glass, gold, paper and membrane where a hydrazide or an aminooxy functional group is bounded; (b) dripping unmodified carbohydrate where a linker is not coupled on the solid substrate of the chip substrate; and (c) reacting the carbohydrate with the solid substrate on the chip substrate at a temperature of 40-60 deg.C for 8-16 hours to selectively and covalently fix the carbohydrate on the solid substrate.