| 摘要 |
FIELD: organic chemistry, pharmacology. ^ SUBSTANCE: claimed method includes reaction of alginic acid with amine-containing compound (RNH2) in presence of condensing agent 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide in aqueous medium at room temperature and pH 4.7-4.8. As amine-containing compounds some pharmacologically value amines are used such as n- and o-aminophenols, 5- and 4-amino salicylic acids, anthranilic acid, and n-aminobenzoic acid, n-aminobenzoic acid ethyl ester (anaesthezine), n-aminobenzoic acid beta-diethylaminoethyl ester (novocaine), nicotinic acid 1-phenyl-2,3-dimethyl-4-aminopyrazolone-5-(4-aminopyrine) hydrazide (isoniaside), 2-amino'thansulfonic acid (taurin), 7-aminocephalosporinic acid, as well as sulfanylamide preparations such as n-aminobenzenesulfacetamide (streptocide), sodium n-aminobenzenesulfacetamide (sodium sulfacyl). ^ EFFECT: new alginic acid derivatives useful in medicine and pharmacology. ^ 1 cl, 14 ex, 1 tbl |
