METHODS OF TREATING AND PREVENTING COLITIS INVOLVING IL-13 AND NK-T CELLS
摘要
<p>A method of treating or preventing the inflammatory response of colitis in a subject comprising administering to the subject an effective amount of a substance that modulates IL-13 activity. The invention also provides a method of treating or preventing the inflammatory response of colitis in a subject comprising administering to the subject an effective amount of a substance that modulates NK-T cell activity. The invention also provides for the screening of substances that treat or prevent the inflammatory response of colitis.
The substance can be an anti-V±14J±281 antibody fragment, an anti-V±24J±18 antibody fragment, an anti-CD1 antibody fragment that inhibits antigen-presentation to NK-T cells or an anti-IL-13 or an anti-IL-13R± antibody fragment that inhibits IL-13 activity.</p>
申请公布号
EP1552462(A4)
申请公布日期
2006.09.20
申请号
EP20020742057
申请日期
2002.06.14
申请人
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;BRIGHAM AND WOMEN'S HOSPITAL, INC.
发明人
STROBER, WARREN;FUSS, IVAN, J.;HELLER, FRANK;BLUMBERG, RICHARD