SEQUENCE DISPOSED UPSTREAM FROM CARP GENE, VECTOR CONTAINING THE SAME AND USES THEREOF

摘要

FIELD: molecular biology, gene engineering, medicine. ^ SUBSTANCE: disclosed is part of nucleotide sequence disposed upstream from encoding sequence of CARP gene having promoter activity providing specific expression of gene operably linked therewith in cardiac cells in vivo. Detected promoter sequence is accepted to mouse CARP gene sequence from nucleotide in (-2266) site to nucleotide in (+92) site. Also disclosed are cassette and vectors for expression of therapeutically valuable target protein in cardiac tissue containing therein said regulatory sequence. ^ EFFECT: genetic constructs useful in pharmaceutical compositions. ^ 19 cl, 10 dwg, 10 ex