发明名称 |
Methods of identifying agents for inhibiting lentivirus replication |
摘要 |
The present invention provides screening methods for identifying a compound that induces loss of the lentiviral protein Vpr; screening methods for identifying compounds that inhibit the peptidyl-prolyl cis/trans isomerase (PPIase) activity of a protein that catalyzes cis-trans isomerization of cis-peptidylprolyl bonds in Vpr; and compounds identified by the screening methods. The compounds are useful for treating a lentiviral infection. The present invention further provides methods of inducing loss of the lentiviral protein Vpr; methods of inhibiting lentivirus viral replication; and methods of treating a lentivirus infection in an individual. The methods generally involve administering to an individual infected with the lentivirus an effective amount of a compound that induces Vpr loss and/or that inhibits PPIase activity of a protein that catalyzes cis-trans isomerization of cis-peptidylprolyl bonds in Vpr.
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申请公布号 |
US7108988(B2) |
申请公布日期 |
2006.09.19 |
申请号 |
US20020285263 |
申请日期 |
2002.10.30 |
申请人 |
THE J. DAVID GLADSTONE INSTITUTES |
发明人 |
SHERMAN MICHAEL;GREENE WARNER;SCHUBERT ULRICH;WRAY VICTOR;TESSMER UWE;HENKLEIN PETER;BRUNS KARSTEN |
分类号 |
C12Q1/70;C12Q1/18;C12Q1/533;G01N33/569 |
主分类号 |
C12Q1/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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