发明名称 |
Liposome composition for improved intracellular delivery of a therapeutic agent |
摘要 |
A liposomal composition and a method of using the same for achieving intracellular delivery of a liposome-entrapped agent is described. The liposomes are composed of a pH sensitive lipid and include a targeting ligand to direct the liposomes to a target cell. The liposomes also include a stabilizing component, such a polymer-derivatized lipid, where the polymer is attached to the lipid by a releasable linkage. Administration of the liposomes results in cellular internalization and destabilization of the liposome for intracellular delivery of the entrapped agent.
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申请公布号 |
US7108863(B2) |
申请公布日期 |
2006.09.19 |
申请号 |
US20020108154 |
申请日期 |
2002.03.26 |
申请人 |
ALZA CORPORATION |
发明人 |
ZALIPSKY SAMUEL;ALLEN THERESA M.;HUANG SHI KUN |
分类号 |
A61B5/055;A61B8/00;A61K9/127;A61K9/133;A61K9/54;A61K39/395;A61K47/24;A61K47/28;A61K47/30;A61K47/34;A61K47/46;A61K47/48 |
主分类号 |
A61B5/055 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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