| 摘要 |
Compounds of formula (I) in which X, Y and Z are independently of one another oxygen, sulphur or NH; R1 represents a group W-V: W is a valence das h or a straight-chained or branched C1-C8 alkyl or a C2-C8 alkenyl group which is optionally once or several times substituted, V is an optionally substituted monocycle or bicycle which can contain one or several heteroatoms, or W-V is a C1-C20 alkyl group which can be interrupted by heteroatoms, one or several carbon atoms are optionally substituted; R2 and R3 represent hydroge n or one of the two represents lower alkyl or lower aryl; R4 and R5 denote independently of each other for A-D, wherein A represents a dash alkyl, alkenyl, acyl, alkylsulfonyl, sulfonyl, alkylaminocarbonyl, aminocarbonyl, alkoxycarbonyl, oxy-carbonyl, alkylaminothiocarbonyl, aminothio-carbonyl which is optionally once or several times substituted; D represents a hydrogen, monocycle or bicycle, the monocycle or bicycle is optionally once or several times interrupted by heteroatoms and the monocycle or bicycle is once or several times substitute d, or R4 and R5 together with the adjacent N atom form a ring; pharmacologicall y acceptable salts and prodrugs thereof and optically active forms, processes for their production and pharmaceutical agents which contain these compounds having am atrix metalloprotease-inhibitory action.
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