发明名称 |
Process for the preparation of optically active amines or salts thereof |
摘要 |
A process produces an optically active amine or its salt and includes the steps of reacting a ketone of Formula (1a): wherein R<SUP>1 </SUP>is typically an unsubstituted or substituted hydrocarbon group; and R<SUP>2a </SUP>is typically a hydrocarbon group having at least one oxo group and optionally having other substituent, with an optically active amine of Formula (2): wherein R<SUP>3 </SUP>is an unsubstituted or substituted aryl group; R<SUP>4 </SUP>is an unsubstituted or substituted lower alkyl group; and C<SUP>1 </SUP>is an asymmetric carbon atom, in the presence of an organic acid to thereby yield a corresponding optically active imine, hydrogenating the imine in the presence of a catalyst to yield a corresponding amine, subjecting the amine or its salt to hydrogenolysis in the presence of a catalyst, and reducing the hydrogenolyzed product with a reducing agent.
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申请公布号 |
US7109350(B2) |
申请公布日期 |
2006.09.19 |
申请号 |
US20040878118 |
申请日期 |
2004.06.29 |
申请人 |
DAICEL CHEMICAL INDUSTRIES, LTD. |
发明人 |
TANAKA HIROKI;PAN LI RUI;IKURA KIYOSHI |
分类号 |
C07D209/54;C07B53/00;C07B61/00;C07C209/00;C07C209/52;C07C209/68;C07C211/03;C07C221/00;C07C249/02;C07C251/16 |
主分类号 |
C07D209/54 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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