摘要 |
Fumaric acid amides of the general formula (I) wherein R<SUP>1 </SUP>represents OR<SUP>3 </SUP>or a D- or L-amino acid radical -NH-CHR<SUP>4</SUP>-COOH bonded via an amide bond, wherein R<SUP>3 </SUP>is hydrogen, a straight-chained or branched, optionally substituted C<SUB>1-24 </SUB>alkyl radical, a phenyl radical or C<SUB>6-10 </SUB>aralkyl radical and R<SUP>4 </SUP>is a side chain of a natural or synthetic amino acid and R<SUP>2 </SUP>represents a D- or L-amino acid radical -NH-CHR<SUP>5</SUP>-COOH bonded via an amide bond or a peptide radical comprising 2 to 100 amino acids bonded via an amide bond, wherein R<SUP>5 </SUP>is a side chain of a natural or synthetic amino acid, are used for preparing a drug (1) for the therapy of an autoimmune disease; (2) for use in transplantation medicine; (3) for the therapy of mitochondrial diseases; or (4) for the therapy of NF-kappaB mediated diseases.
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