| 摘要 |
<p>A process for obtaining membranes loaded with one or more active ingredients, consisting of contacting a solution, or suspension, formed by one or more solvents, one or more polymers and one or more active ingredients with supercritical carbon dioxide (SC-CO<SUB>2</SUB>). SC-CO<SUB>2</SUB>, at suitable process conditions, has a high affinity for organic solvents; therefore, a supercritical fluid solution is formed and a continuous solid structure precipitates. The latter is characterized by interconnected cells (membrane) loaded with the active ingredient initially present in the solution (or suspension). The described process is extremely versatile and allows to obtain membranes with different morphologies, as well as to control the mean cell diameter and porosity.</p> |
