| 摘要 |
<p>The invention relates to a conjugate PT comprising (a) a peptide P and (b) a targeting moiety T; wherein the peptide P contains from 4 to 20 amino acid residues with optionally a single thiol moiety at the C- or N-terminus replacing one of these amino acid residues, and including a complexing amino acid sequence comprising (i) a tridentate or tetradentate planar chelator containing a ligand backbone defined by a perimeter containing - a single sulfur donor atom, - two or three non-sulfur donor atoms, and - intervening atoms between the donor atoms; and (ii) a stabilizing sidechain comprising a further donor atom, the further donor atom being covalently linked to the ligand backbone of the planar chelator through two or three intervening atoms, provided that - said further donor atom is neither the nitrogen nor the oxgen atom of a peptide bond and - if said further donor atom is part of a heterocyclic ring, no more than one of the intervening atoms can be part of that ring; and a radioactive metal complexed to the donor atoms of the planar chelator.</p> |
