39-DESMETHOXY DERIVATIVES OF RAPAMYCIN

摘要

The present invention relates to novel 39-desmethoxyrapamycin derivatives,
methods for their production, and uses thereof. In a further aspect the
present invention provides for the use of these 39-desmethoxyrapamycin
derivatives in the treatment of cancer and / or B-cell malignancies, the
induction or maintenance of immunosuppression, the treatment of
transplantation rejection, graft vs. host disease, autoimmune disorders,
diseases of inflammation, vascular disease and fibrotic diseases, the
stimulation of neuronal regeneration or the treatment of fungal infections.