发明名称 NOVEL SALTS OF QUINUCLIDINE DERIVATIVE
摘要 There is provided an acid addition salt of (-)-(3R)-quinuclidin-3-yl(1R)-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate with an acid selected from the group consisting of (-)-(2S,3S)-tartaric acid, (+)-(2S,3S)-di-O-benzoyltartaric acid, (+)-(2S,3S)-di-O-(4-methylbenzoyl)tartaric acid, (-)-L-phenylalanine, benzenesulfonic acid, cyclohexanesulfamic acid, hydrobromic acid, naphthalene-2-sulfonic acid, sebacic acid, (+)-camphor-10-sulfonic acid, p-toluenesulfonic acid, ethanesulfonic acid, methanesulfonic acid and methyl phosphate, which has little hygroscopicity that affects the use as a drug or its drug substance, and is very useful as a drug or its drug substance.
申请公布号 US2006205770(A1) 申请公布日期 2006.09.14
申请号 US20050128238 申请日期 2005.05.13
申请人 ASTELLAS PHARMA INC. 发明人 HAYAKAWA MASAHIKO;SAMIZU KIYOHIRO;UEBAYASHI HIROSHI;IKEDA KEN;TAKEUCHI MAKOTO
分类号 C07D453/02;A61K31/435;A61K31/439;A61K31/4745;A61P1/00;A61P1/04;A61P11/00;A61P11/06;A61P11/08;A61P13/00;A61P25/00;A61P27/16 主分类号 C07D453/02
代理机构 代理人
主权项
地址