发明名称 |
COMPOSITIONS, ORGANISMS AND METHODOLOGIES EMPLOYING A NOVEL HUMAN KINASE |
摘要 |
This invention provides compositions, organisms and methodologies employing a novel human protein kinase, MCRKI . The novel human kinase has sequence homology to rat myotonic dystrophy kinase-related Cdc42 binding kinase (MRCK) alpha. The gene encoding the novel kinase is localized in locus 11 q13 of human chromosome 11. The novel protein kinase comprises multiple functional/structural domains that include a kinase domain, a pkinase_C domain, a DAG-PE binding domain, and a CNH domain. The sequence and structure similarity between the novel human protein and rat MRCK alpha indicates that the novel human protein may function as a downstream effector of Cdc42 in cytoskeleton reorganization. |
申请公布号 |
WO2004050831(A3) |
申请公布日期 |
2006.09.14 |
申请号 |
WO2003US35609 |
申请日期 |
2003.11.07 |
申请人 |
WYETH;LIU, WEI;WU, LEEYING;CHEN, HUIMIN |
发明人 |
LIU, WEI;WU, LEEYING;CHEN, HUIMIN |
分类号 |
C12N15/54;C12N1/21;C12N5/10;C12N9/12 |
主分类号 |
C12N15/54 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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