摘要 |
Promoters that include a tissue-selective promoter sequence and a second promoter sequence operatively coupled to the tissue-selective promoter sequence, wherein the second promoter sequence includes a minimal viral promoter sequence, are disclosed. Nucleic acids and compositions that include these promoter sequences are also disclosed. Also disclosed are methods of improving the function of a tissue-selective promoter, involving operatively coupling a tissue-selective promoter sequence with a second promoter sequence that includes a minimal viral promoter sequence. Also disclosed are methods of delivering a gene into a cell, methods of treating a subject with a hyperproliferative disease, and methods of imaging a cell that involve use of the novel promoter sequences set forth herein. |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM;FANG, BINGLIANG;ROTH, JACK, A.;JI, LINX. |
发明人 |
FANG, BINGLIANG;ROTH, JACK, A.;JI, LINX. |