| 摘要 |
<p>A compound having an 11ß-HSD1 inhibiting potency. Compounds of the general formula: (wherein all the characters have the same meanings as defined in the description), their salts or hydrates and prodrugs thereof have an 11ß-HSD1 inhibiting potency and thus are useful in the prevention and/or treatment of diseases attributed to overproduction of adrenocortical hormone, for example, metabolic diseases (for example, diabetes mellitus (e.g., type II diabetes mellitus, etc.), impaired glucose tolerance, hyperglycemia, insulin resistance, elevated levels of insulin in the plasma, lipid metabolism abnormality, fatty liver, dyslipidemia, hyperlipemia, hypertriglyceridemia, hyper-LDL-cholesterolemia, hypo-HDL-cholesterolemia, obesity, atherosclerosis, syndrome X, metabolic syndrome, Cushing's syndrome, osteoporosis, etc.), hypertension, receptive defect, memory disorder, depression, anxiety, dementia, Alzheimer disease, glaucoma, immunologic disease, etc.</p> |
