INHIBITOR OF PLASMINOGEN ACTIVATOR INHIBITOR-1

摘要

A pharmaceutical agent comprising a compound represented by the general formula (I) or a salt thereof as an active ingredient and having an inhibitory effect against plasminogen activator inhibitor-1: wherein each of R<SUP>1</SUP> and R<SUP>2</SUP> represents an aromatic group; W represents a group selected from the connecting groups shown in the group W-1 below; and Z represents a single bond or a connecting group having 1 to 3 atoms in the backbone: , wherein the bond on the left-hand side attaches to a carbon atom and the bond on the right-hand side attaches to a nitrogen atom; X represents a sulfur atom or NH; Y represents an oxygen or sulfur atom; and R<SUP>3</SUP> represents a hydrocarbon, hydroxy or carboxy group.