BIOACTIVE STENTS FOR TYPE II DIABETICS AND METHODS FOR USE THEREOF
摘要
The present invention is based on the discovery that a vascular stent or other implantable medical device can be coated with a biodegradable biocompatible polymer to which is attached a bioligand that specifically captures progenitors of endothelial cells (PECs) from the circulating blood to promote endogenous formation of healthy endothelium in Type II diabetics. In one embodiment, the bioligand is a peptide that specifically binds to an integrin receptor on PECs. The invention also provides methods for using such vascular stents and other implantable devices to promote vascular healing in Type II diabetics, for example following mechanical intervention.
申请公布号
WO2005097186(A3)
申请公布日期
2006.09.14
申请号
WO2005US11231
申请日期
2005.04.04
申请人
MEDIVAS, LLC;CARPENTER, KENNETH, W.;TURNELL, WILLIAM, G.;DEFIFE, KRISTEN, M.;GRAKO, KATHRYN, A.
发明人
CARPENTER, KENNETH, W.;TURNELL, WILLIAM, G.;DEFIFE, KRISTEN, M.;GRAKO, KATHRYN, A.