发明名称 |
SUBSTITUTED PYRIDO[3',2':4,5]THIENO[3,2-D]PYRIMIDINE-2,4(1 H,3H)-DIONES AND -4(3H)-ONES, PYRIDO[3',2':4,5]FURO[3,2-D]PYRIMIDINE-2,4(1 H,3H)-DIONES AND -4(3H)-ONES, AND USE THEREOF AS INHIBITORS OF TNF-ALPHA RELEASE |
摘要 |
The invention relates to novel pyrido[3',2':4,5]thieno[3,2-d]pyrimidine-2,4(1 H,3H)-diones and -4(3H)-one (X=C-H, Y=S), thieno[2,3-d:4,5-d']dipyrimidine-2,4(1 H,3H)-diones and -4(3H)-one (X=N, Y=S), in addition to pyrido[3',2':4,5]furo[3,2-d]pyrimidine-2,4(1 H,3H)-diones and -4(3H)-one (X=C-H, Y=0) and furo[2,3-d:4,5-d']dipyrimidine-2,4(1 H,3H)-diones and -4(3H)-one (X=N, Y=O) of general formulae 1a and 1b. The invention also relates to a method for the production thereof, pharmaceutical preparations containing said compounds and/or tautomers thereof and physiologically compatible salts which can be produced therefrom and/or solvates thereof, in addition to the pharmaceutical use of said compounds, tautomers thereof, salts or solvates, as inhibitors of TNFa-release. |
申请公布号 |
WO2006010568(A3) |
申请公布日期 |
2006.09.14 |
申请号 |
WO2005EP08031 |
申请日期 |
2005.07.22 |
申请人 |
CURACYTE DISCOVERY GMBH;REICHELT, CLAUDIA;LUDWIG, ALEXANDER;SCHULZE, ALEXANDER;DAGHISH, MOHAMMED;LEISTNER, SIEGFRIED |
发明人 |
REICHELT, CLAUDIA;LUDWIG, ALEXANDER;SCHULZE, ALEXANDER;DAGHISH, MOHAMMED;LEISTNER, SIEGFRIED |
分类号 |
C07D495/14;A61K31/519;A61P9/10;C07D491/14 |
主分类号 |
C07D495/14 |
代理机构 |
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