ENVIRONMENTALLY STABLE SENSORS AND METHODS OF USING THE SAME
摘要
<p>Environmentally stable biosensors are disclosed, which comprise a ligand binding domain from a thermophilic organism conjugated to donor and fluorescent moieties that permit detection and measurement of Fluorescence Resonance Energy Transfer upon ligand binding. Such biosensors demonstrate enhanced acid-, thermal- and chemical stability as compared to sensors constructed using protein domains from mesophilic organisms.</p>
申请公布号
WO2006096214(A1)
申请公布日期
2006.09.14
申请号
WO2005US36954
申请日期
2005.10.14
申请人
CARNEGIE INSTITUTION OF WASHINGTON;FROMMER, WOLF, B.;LOGER, LOREN