| 摘要 |
Methods and compositions are disclosed for detecting and depleting cells infected with bacteria of the Chlamydiaceae family from a biological sample. Compositions include, for example, an immunoglobulin constant region polypeptide linked to an imaging moiety or a bactericide. Methods include, for example, contacting a biological sample that includes chlamydia infected cells, with a composition that includes an immunoglobulin constant region polypeptide linked to a detectable moiety, wherein the composition is selectively taken up by chlamydia infected cells and thereby detectably labels them. Methods of depleting chlamydia infected cells include for example, contacting a biological sample that includes chlamydia infected cells with a composition that includes an immunoglobulin constant region polypeptide linked to a bactericide, wherein the composition is selectively taken up by the infected cells and comes into contact with intracellular chlamydial bacteria and can thereby kill them or inhibit their replication.
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