<p>A method is provided for identifying a compound that modulates a cellular response associated with Homer and mediated by a cell-surface or an intracellular receptor. A method is further provided for identifying a compound that modulates receptor activated calcium mobilization associated with Homer. A method is provided for identifying a compound that inhibits Homer protein activity based on the crystal structure coordinates of Homer protein binding domain. A method is also provided for identifying a compound that affects the formation of cell surface receptors into clusters. Also provided are nucleic acids encoding Homer proteins as well as Homer proteins, and Homer interacting proteins.
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申请公布号
EP1662255(A3)
申请公布日期
2006.09.13
申请号
EP20060003521
申请日期
1999.08.18
申请人
THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE
发明人
WORLEY, PAUL F.;TU, JIAN CHENG;XIAO, BO;LEAHY, DANIEL;BENEKEN, JUTTA;LANAHAN, ANTHONY A.