cDNAs and proteins involved in hypoxia, circadian and orphan signal transduction pathways, and methods of use

摘要

The present invention provides isolated nucleic acids and proteins that are new and distinct members of the bHLH-PAS superfamily of transcription regulators. These "MOPs" (members of PAS) are useful in a variety of research, diagnostic and therapeutic applications. Several of the MOPs of the present invention are alpha-class hypoxia-inducible factors. Several other of the MOPs of the invention are involved in circadian signal transduction.