发明名称 |
CIS-2,4,5-TRIPHENYL-IMIDAZOLINES AND THEIR USE IN THE TREATMENT OF TUMORS |
摘要 |
The present invention provides compounds according to formula I and formula II and pharmaceutically acceptable salts ad esters thereof, having the designations provides herein and which inhibit the interaction of MDM2 protein with a p53-like peptide and have antiproliferative activity. Formula (I).
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申请公布号 |
KR20060096513(A) |
申请公布日期 |
2006.09.11 |
申请号 |
KR20067016636 |
申请日期 |
2006.08.18 |
申请人 |
F. HOFFMANN-LA ROCHE AG |
发明人 |
KONG NORMAN;LIU EMILY AIJUN;VU BINH THANH |
分类号 |
A61K31/4164;A61K31/454;A61K31/496;A61K31/5377;A61P35/00;A61P43/00;C07D233/22;C07D233/24;C07D233/26;C07D401/06;C07D403/06;C07D403/12;C07D405/04;C07D409/06;C07D413/06 |
主分类号 |
A61K31/4164 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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