| 摘要 |
A T-type calcium channel inhibitor which is any of a compound represented by the formula (1): [Chemical formula 1] (1) [wherein Ar1 means phenyl, pyridyl, furyl, or 2,1,3- benzoxadiazol-4-yl; the nitrogenous heterocycle moiety is a 1,4- dihydropyridine ring or pyridine ring; Z means the formula (2): [Chemical formula 2] (2) or CO2R2; Ra and Rb each independently means C1-6 alkyl, ANR8R9, CH2OANR8R9, etc.; when the nitrogenous heterocycle means a 1,4-dihydropyridine ring, then R1 means C 1-6 alkyl, ANR8R9, AN(CH2CH2) 2NR8, AN(CH2CH2)2O, AOR8, or benzyl; and R3 means hydrogen, C1-20 alkyl, ANR 8R9, or a group represented by any of the following formulae], [Chemical formula 3] a pharmaceutically acceptable salt of the compound, and a solvate of either.
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