NEW SUBSTANCES BINDING TO HELICOBACTER PILORI AND USES THEREOF

摘要

FIELD: medicine, pharmaceuticals. ^ SUBSTANCE: disclosed are agent of formula I binding to Helicobacter pilori ex vivo and substance based thereon, as well as pharmaceutical composition, food supplement and method for identification of bacterial adhesine. Claimed substance comprises agent of formula 1 and carrier. In particular substance includes Galbeta3GlcNAc. Said agent may by conjugated with oligosaccharide or ceramide. Claimed agent represents specifically binding epitope of lactotetraose or lactotetraosyl ceramide (Galbeta3GlcNAcbeta3Galbeta-4Glc1Cer) having lactotetraosyl ceramide sfingolipide-like activity, and is useful in typing of Helicobacter pilori, in Helicobacter pilori binding inhibition and in identification of bacterial adhesine. ^ EFFECT: new substances for binding to Helicobacter pilori. ^ 18 cl, 13 dwg, 3 tbl