发明名称 |
Immediate release formulations of 1-aminocyclohexane compounds, memantine and neramexane |
摘要 |
The present invention relates to an immediate release solid oral dosage form containing 1-aminocyclohexanes, preferably memantine or neramexane, and optionally a pharmaceutically acceptable coating, wherein the active ingredient exhibits dose proportionality and is released at a dissolution rate of more than about 80% within about the first 60 minutes following entry of said form into a use environment. The dosage form is direct compressed and has a hardness within the range of between about 3 and about 40 Kp, exhibits an average T<SUB>max </SUB>within the range of about 2 to about 8 hours with an active ingredient load within the range of about 2.5 to about 150 mg. The formulation allows for dose-proportional compositions for once daily or b.i.d. dosing, while maintaining a steady average range of T<SUB>max</SUB>.
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申请公布号 |
US2006198884(A1) |
申请公布日期 |
2006.09.07 |
申请号 |
US20050304976 |
申请日期 |
2005.12.14 |
申请人 |
FOREST LABORATORIES, INC. |
发明人 |
YANG YAN;JANJIKHEL RAJIV;RAO NIRANJAN;PERICLOU ANTONIA;ABRAMOWITZ WATTANAPORN;DEDHIYA MAHENDRA G.;SEILLER ERHARD;HAUPTMEIER BERNHARD |
分类号 |
A61K31/13;A61K9/20 |
主分类号 |
A61K31/13 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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