发明名称 |
PTH functional domain conjugate peptides, derivatives thereof and novel tethered ligand-receptor molecules |
摘要 |
Novel parathyroid hormone (PTH) peptides and analogs thereof of the PTH(1-34) fragment are disclosed that combine the N-terminal signaling domain (residues 1-9) and the C-terminal binding domain (residues 15-31) via a linker. Nucleic acid molecules and peptides for PTH(1-9)-(Gly)5-PTH(15-31) (PG5) and PTH(1-9)-(Gly)7-PTH(15-31) and a novel PTH receptor are disclosed. Additionally, methods of screening for PTH agonists, pharmaceutical compositions and methods of treatment are disclosed.
|
申请公布号 |
US2006199765(A1) |
申请公布日期 |
2006.09.07 |
申请号 |
US20060366391 |
申请日期 |
2006.03.03 |
申请人 |
GARDELLA THOMAS J;KRONENBERG HENRY M;POTTS JOHN T JR;JUPPNER HARALD |
发明人 |
GARDELLA THOMAS J.;KRONENBERG HENRY M.;POTTS JOHN T.JR.;JUPPNER HARALD |
分类号 |
C07K14/635 |
主分类号 |
C07K14/635 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|