Optimally expanded, collagen sealed ePTFE graft with improved tissue ingrowth

摘要

The present invention provides a method of making a temporarily blood-tight implantable ePTFE material for improved tissue ingrowth and delivery of therapeutic agents comprising providing an ePTFE material having an average internodal distance of 60-200 microns, preparing a biodegradable hydrogel sealant also comprising a therapeutic agent infusing the ePTFE material with the biodegradable hydrogel sealant, and curing the ePTFE material.