发明名称 |
Compositions and methods for short interfering nucleic acid inhibition of NAv1.8 |
摘要 |
The invention provides short interfering nucleic acids, either single-stranded or double-stranded, that cause RNAi-induced degradation of mRNA from the Na<SUB>v</SUB>1.8 sodium channel gene; to pharmaceutical compositions comprising such short interfering nucleic acids; recombinant vectors comprising such short interfering nucleic acids; a method for inhibiting translation of an mRNA; a method for inhibiting expression of a polypeptide; a method for blocking the membrane potential in a cell; a method for blocking the sodium current in a cell; and a method for inhibiting chronic pain.
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申请公布号 |
US2006199779(A1) |
申请公布日期 |
2006.09.07 |
申请号 |
US20050259588 |
申请日期 |
2005.10.26 |
申请人 |
SCHERING CORPORATION |
发明人 |
GOREGAOKER SAMEER;HUNTER JOHN C.;PRIESTLEY TONY |
分类号 |
A61K48/00;C07H21/02;C12N15/113 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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