发明名称 |
Peptide drugs for chronic lymphocytic leukemia (CLL) and other cancers |
摘要 |
The present invention provides a modified BAD peptide or peptidomimetic which includes an amino acid sequence having at least 60% amino acid identity with SEQ ID NO: 1, where the modified BAD peptide or peptidomimetic has enhanced affinity for Bcl-2 as compared to wild type BAD peptide (SEQ ID NO: 1). Further provided herein is a composition containing a delivery agent and a modified BAD peptide or peptidomimetic which includes an amino acid sequence having at least 60% amino acid identity with SEQ ID NO: 1, where the modified BAD peptide or peptidomimetic has enhanced affinity for Bcl-2 as compared to wild type BAD peptide (SEQ ID NO: 1).
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申请公布号 |
US2006198832(A1) |
申请公布日期 |
2006.09.07 |
申请号 |
US20050267828 |
申请日期 |
2005.11.03 |
申请人 |
SATTERTHWAIT ARNOLD;ZHU XIUWEN;KITADA SHINICHI;REED JOHN |
发明人 |
SATTERTHWAIT ARNOLD;ZHU XIUWEN;KITADA SHINICHI;REED JOHN |
分类号 |
A61K38/54;C12N9/99 |
主分类号 |
A61K38/54 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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