AUFLÖSUNG VON TRANS-2 (ALKOXYCARBONYLETHYL)-LACTAMEN, NÜTZLICH BEI DER SYNTHESE VON 1-(4-FLUOROPHENYL)-[3(R)-3(S)-HYDROXY-3-(4-FLUOROPHENYL)PROPYL]-4(S)-(4-HYDROXYPHENYL)-2-AZETIDINONE

摘要

A process for the microbiological or enzymatic hydrolytic resolution of racemic trans-2-(alkoxycarbonylethyl) lactams of the formula I: wherein R is C1-C7 alkyl, 2,2,2-trifluoroethyl or methoxyethoxyethyl and R1 is hydrogen or a protecting group is disclosed, whereby an optically enriched compound of the formula Ib or IIa: is obtained.