| 发明名称 | 盐酸伊伐布雷定的γd－晶形、其制备方法和含有它的药物组合物 | ||
| 摘要 | 通式(I)的盐酸伊伐布雷定的γd－晶形，其特征在于其粉末X射线衍射图。药物。 | ||
| 申请公布号 | CN1827601A | 申请公布日期 | 2006.09.06 |
| 申请号 | CN200610058077.X | 申请日期 | 2006.02.28 |
| 申请人 | 瑟维尔实验室 | 发明人 | S·霍瓦特;M－N·奥古斯特;G·达米安 |
| 分类号 | C07D223/16(2006.01);A61K31/55(2006.01);A61P9/04(2006.01);A61P9/06(2006.01);A61P9/10(2006.01) | 主分类号 | C07D223/16(2006.01) |
| 代理机构 | 北京市中咨律师事务所 | 代理人 | 黄革生;隗永良 |
| 主权项 | 1.通式(I)的盐酸伊伐布雷定的γd-晶形：<img file="A2006100580770002C1.GIF" wi="1481" he="438" />其特征在于如下粉末X射线衍射图，所述衍射图使用PANalytical X’PertPro衍射仪与X’Celerator检测器测定，并根据谱线位置(布拉格角2θ，以度表示)、谱线高度(以计数表示)、谱线面积(以计数×度表示)、半高处的谱线宽度(“FWHM”，以度表示)和晶面间距d(以_表示)表示：<tables id="table1" num="001"><table width="744"><tgroup cols="6"><colspec colname="c001" colwidth="19%" /><colspec colname="c002" colwidth="15%" /><colspec colname="c003" colwidth="17%" /><colspec colname="c004" colwidth="15%" /><colspec colname="c005" colwidth="17%" /><colspec colname="c006" colwidth="16%" /><thead><row><entry morerows="1"> 谱线号 </entry><entry morerows="1"> 2θ角 (度) </entry><entry morerows="1"> 高 (计数) </entry><entry morerows="1"> 面积 (计数 ×度)</entry><entry morerows="1"> FWHM (度) </entry><entry morerows="1"> 晶面间距 (_) </entry></row></thead><tbody><row><entry morerows="1"> 1</entry><entry morerows="1"> 4.3</entry><entry morerows="1"> 1077</entry><entry morerows="1"> 124</entry><entry morerows="1"> 0.1171</entry><entry morerows="1"> 20.633</entry></row><row><entry morerows="1"> 2</entry><entry morerows="1"> 6.9</entry><entry morerows="1"> 132</entry><entry morerows="1"> 70</entry><entry morerows="1"> 0.5353</entry><entry morerows="1"> 12.787</entry></row><row><entry morerows="1"> 3</entry><entry morerows="1"> 8.4</entry><entry morerows="1"> 269</entry><entry morerows="1"> 35</entry><entry morerows="1"> 0.1338</entry><entry morerows="1"> 10.482</entry></row><row><entry morerows="1"> 4</entry><entry morerows="1"> 10.6</entry><entry morerows="1"> 322</entry><entry morerows="1"> 26</entry><entry morerows="1"> 0.0836</entry><entry morerows="1"> 8.310</entry></row><row><entry morerows="1"> 5</entry><entry morerows="1"> 11.9</entry><entry morerows="1"> 733</entry><entry morerows="1"> 97</entry><entry morerows="1"> 0.1338</entry><entry morerows="1"> 7.414</entry></row><row><entry morerows="1"> 6</entry><entry morerows="1"> 12.5</entry><entry morerows="1"> 1406</entry><entry morerows="1"> 278</entry><entry morerows="1"> 0.2007</entry><entry morerows="1"> 7.069</entry></row><row><entry morerows="1"> 7</entry><entry morerows="1"> 13.4</entry><entry morerows="1"> 2975</entry><entry morerows="1"> 442</entry><entry morerows="1"> 0.1506</entry><entry morerows="1"> 6.619</entry></row><row><entry morerows="1"> 8</entry><entry morerows="1"> 14.4</entry><entry morerows="1"> 825</entry><entry morerows="1"> 122</entry><entry morerows="1"> 0.1506</entry><entry morerows="1"> 6.134</entry></row><row><entry morerows="1"> 9</entry><entry morerows="1"> 15.8</entry><entry morerows="1"> 1036</entry><entry morerows="1"> 205</entry><entry morerows="1"> 0.2007</entry><entry morerows="1"> 5.598</entry></row><row><entry morerows="1"> 10</entry><entry morerows="1"> 16.3</entry><entry morerows="1"> 540</entry><entry morerows="1"> 107</entry><entry morerows="1"> 0.2007</entry><entry morerows="1"> 5.450</entry></row><row><entry morerows="1"> 11</entry><entry morerows="1"> 16.9</entry><entry morerows="1"> 1007</entry><entry morerows="1"> 183</entry><entry morerows="1"> 0.184</entry><entry morerows="1"> 5.233</entry></row><row><entry morerows="1"> 12</entry><entry morerows="1"> 17.8</entry><entry morerows="1"> 499</entry><entry morerows="1"> 58</entry><entry morerows="1"> 0.1171</entry><entry morerows="1"> 4.978</entry></row><row><entry morerows="1"> 13</entry><entry morerows="1"> 18.9</entry><entry morerows="1"> 1062</entry><entry morerows="1"> 140</entry><entry morerows="1"> 0.1338</entry><entry morerows="1"> 4.686</entry></row></tbody></tgroup></table></tables><tables id="table2" num="002"><table width="746"><tgroup cols="6"><colspec colname="c001" colwidth="19%" /><colspec colname="c002" colwidth="15%" /><colspec colname="c003" colwidth="17%" /><colspec colname="c004" colwidth="15%" /><colspec colname="c005" colwidth="17%" /><colspec colname="c006" colwidth="16%" /><thead><row><entry morerows="1"> 谱线号 </entry><entry morerows="1"> 2θ角 (度) </entry><entry morerows="1"> 高 (计数) </entry><entry morerows="1"> 面积 (计数 ×度)</entry><entry morerows="1"> FWHM (度) </entry><entry morerows="1"> 晶面间距 (_) </entry></row></thead><tbody><row><entry morerows="1"> 14</entry><entry morerows="1"> 19.8</entry><entry morerows="1"> 570</entry><entry morerows="1"> 85</entry><entry morerows="1"> 0.1506</entry><entry morerows="1"> 4.485</entry></row><row><entry morerows="1"> 15</entry><entry morerows="1"> 20.2</entry><entry morerows="1"> 549</entry><entry morerows="1"> 63</entry><entry morerows="1"> 0.1171</entry><entry morerows="1"> 4.399</entry></row><row><entry morerows="1"> 16</entry><entry morerows="1"> 20.9</entry><entry morerows="1"> 2565</entry><entry morerows="1"> 635</entry><entry morerows="1"> 0.2509</entry><entry morerows="1"> 4.241</entry></row><row><entry morerows="1"> 17</entry><entry morerows="1"> 21.6</entry><entry morerows="1"> 531</entry><entry morerows="1"> 105</entry><entry morerows="1"> 0.2007</entry><entry morerows="1"> 4.104</entry></row><row><entry morerows="1"> 18</entry><entry morerows="1"> 22.3</entry><entry morerows="1"> 213</entry><entry morerows="1"> 35</entry><entry morerows="1"> 0.1673</entry><entry morerows="1"> 3.981</entry></row><row><entry morerows="1"> 19</entry><entry morerows="1"> 23.4</entry><entry morerows="1"> 278</entry><entry morerows="1"> 27</entry><entry morerows="1"> 0.1004</entry><entry morerows="1"> 3.807</entry></row><row><entry morerows="1"> 20</entry><entry morerows="1"> 24.1</entry><entry morerows="1"> 1404</entry><entry morerows="1"> 185</entry><entry morerows="1"> 0.1338</entry><entry morerows="1"> 3.694</entry></row><row><entry morerows="1"> 21</entry><entry morerows="1"> 24.4</entry><entry morerows="1"> 1526</entry><entry morerows="1"> 176</entry><entry morerows="1"> 0.1171</entry><entry morerows="1"> 3.650</entry></row><row><entry morerows="1"> 22</entry><entry morerows="1"> 24.8</entry><entry morerows="1"> 676</entry><entry morerows="1"> 100</entry><entry morerows="1"> 0.1506</entry><entry morerows="1"> 3.591</entry></row><row><entry morerows="1"> 23</entry><entry morerows="1"> 25.4</entry><entry morerows="1"> 702</entry><entry morerows="1"> 139</entry><entry morerows="1"> 0.2007</entry><entry morerows="1"> 3.504</entry></row><row><entry morerows="1"> 24</entry><entry morerows="1"> 26.2</entry><entry morerows="1"> 1737</entry><entry morerows="1"> 401</entry><entry morerows="1"> 0.2342</entry><entry morerows="1"> 3.403</entry></row><row><entry morerows="1"> 25</entry><entry morerows="1"> 26.8</entry><entry morerows="1"> 258</entry><entry morerows="1"> 51</entry><entry morerows="1"> 0.2007</entry><entry morerows="1"> 3.331</entry></row><row><entry morerows="1"> 26</entry><entry morerows="1"> 27.2</entry><entry morerows="1"> 182</entry><entry morerows="1"> 24</entry><entry morerows="1"> 0.1338</entry><entry morerows="1"> 3.282</entry></row><row><entry morerows="1"> 27</entry><entry morerows="1"> 27.9</entry><entry morerows="1"> 838</entry><entry morerows="1"> 249</entry><entry morerows="1"> 0.3011</entry><entry morerows="1"> 3.193</entry></row><row><entry morerows="1"> 28</entry><entry morerows="1"> 29.1</entry><entry morerows="1"> 152</entry><entry morerows="1"> 20</entry><entry morerows="1"> 0.1338</entry><entry morerows="1"> 3.071</entry></row></tbody></tgroup></table></tables> | ||
| 地址 | 法国库伯瓦 | ||