| 发明名称 | 盐酸伊伐布雷定的γ－晶形、其制备方法和含有它的药物组合物 | ||
| 摘要 | 通式(I)的盐酸伊伐布雷定的γ－晶形，其特征在于其粉末X射线衍射图。药物。 | ||
| 申请公布号 | CN1827602A | 申请公布日期 | 2006.09.06 |
| 申请号 | CN200610058078.4 | 申请日期 | 2006.02.28 |
| 申请人 | 瑟维尔实验室 | 发明人 | S·霍瓦特;M－N·奥古斯特;G·达米安 |
| 分类号 | C07D223/16(2006.01);A61K31/55(2006.01);A61P9/04(2006.01);A61P9/06(2006.01);A61P9/10(2006.01) | 主分类号 | C07D223/16(2006.01) |
| 代理机构 | 北京市中咨律师事务所 | 代理人 | 黄革生;林柏楠 |
| 主权项 | 1.通式(I)的盐酸伊伐布雷定的γ-晶形：<img file="A2006100580780002C1.GIF" wi="1360" he="371" />其特征在于如下粉末X射线衍射图，所述衍射图使用PANalytical X’PertPro衍射仪与X’Celerator检测器测定，并根据谱线位置(布拉格角2θ，以度表示)、谱线高度(以计数表示)、谱线面积(以计数×度表示)、半高处的谱线宽度(“FWHM”，以度表示)和晶面间距d(以_表示)表示：<tables id="table1" num="001"><table width="738"><tgroup cols="6"><colspec colname="c001" colwidth="19%" /><colspec colname="c002" colwidth="15%" /><colspec colname="c003" colwidth="17%" /><colspec colname="c004" colwidth="15%" /><colspec colname="c005" colwidth="16%" /><colspec colname="c006" colwidth="16%" /><thead><row><entry morerows="1"> 谱线号</entry><entry morerows="1"> 2θ角 (度)</entry><entry morerows="1"> 高 (计数)</entry><entry morerows="1"> 面积(计 数×度)</entry><entry morerows="1"> FWHM (度)</entry><entry morerows="1"> 晶面间距 (_)</entry></row></thead><tbody><row><entry morerows="1"> 1</entry><entry morerows="1"> 4.2</entry><entry morerows="1"> 1456</entry><entry morerows="1"> 144</entry><entry morerows="1"> 0.1004</entry><entry morerows="1"> 20.762</entry></row><row><entry morerows="1"> 2</entry><entry morerows="1"> 6.9</entry><entry morerows="1"> 125</entry><entry morerows="1"> 99</entry><entry morerows="1"> 0.8029</entry><entry morerows="1"> 12.880</entry></row><row><entry morerows="1"> 3</entry><entry morerows="1"> 8.4</entry><entry morerows="1"> 182</entry><entry morerows="1"> 18</entry><entry morerows="1"> 0.1004</entry><entry morerows="1"> 10.503</entry></row><row><entry morerows="1"> 4</entry><entry morerows="1"> 10.7</entry><entry morerows="1"> 240</entry><entry morerows="1"> 32</entry><entry morerows="1"> 0.1338</entry><entry morerows="1"> 8.249</entry></row><row><entry morerows="1"> 5</entry><entry morerows="1"> 11.3</entry><entry morerows="1"> 74</entry><entry morerows="1"> 15</entry><entry morerows="1"> 0.2007</entry><entry morerows="1"> 7.858</entry></row><row><entry morerows="1"> 6</entry><entry morerows="1"> 12.0</entry><entry morerows="1"> 644</entry><entry morerows="1"> 64</entry><entry morerows="1"> 0.1004</entry><entry morerows="1"> 7.392</entry></row><row><entry morerows="1"> 7</entry><entry morerows="1"> 12.5</entry><entry morerows="1"> 1476</entry><entry morerows="1"> 219</entry><entry morerows="1"> 0.1506</entry><entry morerows="1"> 7.060</entry></row><row><entry morerows="1"> 8</entry><entry morerows="1"> 13.4</entry><entry morerows="1"> 2691</entry><entry morerows="1"> 400</entry><entry morerows="1"> 0.1506</entry><entry morerows="1"> 6.612</entry></row><row><entry morerows="1"> 9</entry><entry morerows="1"> 14.5</entry><entry morerows="1"> 541</entry><entry morerows="1"> 80</entry><entry morerows="1"> 0.1506</entry><entry morerows="1"> 6.119</entry></row><row><entry morerows="1"> 10</entry><entry morerows="1"> 14.8</entry><entry morerows="1"> 104</entry><entry morerows="1"> 17</entry><entry morerows="1"> 0.1673</entry><entry morerows="1"> 5.981</entry></row><row><entry morerows="1"> 11</entry><entry morerows="1"> 15.9</entry><entry morerows="1"> 815</entry><entry morerows="1"> 67</entry><entry morerows="1"> 0.0836</entry><entry morerows="1"> 5.559</entry></row><row><entry morerows="1"> 12</entry><entry morerows="1"> 16.3</entry><entry morerows="1"> 501</entry><entry morerows="1"> 74</entry><entry morerows="1"> 0.1506</entry><entry morerows="1"> 5.419</entry></row></tbody></tgroup></table></tables><tables id="table2" num="002"><table width="739"><tgroup cols="6"><colspec colname="c001" colwidth="19%" /><colspec colname="c002" colwidth="15%" /><colspec colname="c003" colwidth="17%" /><colspec colname="c004" colwidth="15%" /><colspec colname="c005" colwidth="17%" /><colspec colname="c006" colwidth="16%" /><thead><row><entry morerows="1"> 谱线号 </entry><entry morerows="1"> 2θ角 (度)</entry><entry morerows="1"> 高 (计数)</entry><entry morerows="1"> 面积(计 数×度)</entry><entry morerows="1"> FWHM (度)</entry><entry morerows="1"> 晶面间距 (_)</entry></row></thead><tbody><row><entry morerows="1"> 13</entry><entry morerows="1"> 17.0</entry><entry morerows="1"> 1168</entry><entry morerows="1"> 154</entry><entry morerows="1"> 0.1338</entry><entry morerows="1"> 5.210</entry></row><row><entry morerows="1"> 14</entry><entry morerows="1"> 17.9</entry><entry morerows="1"> 430</entry><entry morerows="1"> 43</entry><entry morerows="1"> 0.1004</entry><entry morerows="1"> 4.962</entry></row><row><entry morerows="1"> 15</entry><entry morerows="1"> 19.0</entry><entry morerows="1"> 667</entry><entry morerows="1"> 121</entry><entry morerows="1"> 0.184</entry><entry morerows="1"> 4.672</entry></row><row><entry morerows="1"> 16</entry><entry morerows="1"> 19.8</entry><entry morerows="1"> 527</entry><entry morerows="1"> 104</entry><entry morerows="1"> 0.2007</entry><entry morerows="1"> 4.483</entry></row><row><entry morerows="1"> 17</entry><entry morerows="1"> 20.2</entry><entry morerows="1"> 726</entry><entry morerows="1"> 144</entry><entry morerows="1"> 0.2007</entry><entry morerows="1"> 4.392</entry></row><row><entry morerows="1"> 18</entry><entry morerows="1"> 20.5</entry><entry morerows="1"> 282</entry><entry morerows="1"> 28</entry><entry morerows="1"> 0.1004</entry><entry morerows="1"> 4.323</entry></row><row><entry morerows="1"> 19</entry><entry morerows="1"> 21.1</entry><entry morerows="1"> 2255</entry><entry morerows="1"> 260</entry><entry morerows="1"> 0.1171</entry><entry morerows="1"> 4.208</entry></row><row><entry morerows="1"> 20</entry><entry morerows="1"> 21.4</entry><entry morerows="1"> 694</entry><entry morerows="1"> 68</entry><entry morerows="1"> 0.1004</entry><entry morerows="1"> 4.147</entry></row><row><entry morerows="1"> 21</entry><entry morerows="1"> 21.6</entry><entry morerows="1"> 744</entry><entry morerows="1"> 86</entry><entry morerows="1"> 0.1171</entry><entry morerows="1"> 4.111</entry></row><row><entry morerows="1"> 22</entry><entry morerows="1"> 22.3</entry><entry morerows="1"> 175</entry><entry morerows="1"> 35</entry><entry morerows="1"> 0.2007</entry><entry morerows="1"> 3.987</entry></row><row><entry morerows="1"> 23</entry><entry morerows="1"> 23.5</entry><entry morerows="1"> 310</entry><entry morerows="1"> 61</entry><entry morerows="1"> 0.2007</entry><entry morerows="1"> 3.784</entry></row><row><entry morerows="1"> 24</entry><entry morerows="1"> 24.2</entry><entry morerows="1"> 1635</entry><entry morerows="1"> 270</entry><entry morerows="1"> 0.1673</entry><entry morerows="1"> 3.683</entry></row><row><entry morerows="1"> 25</entry><entry morerows="1"> 24.5</entry><entry morerows="1"> 1335</entry><entry morerows="1"> 220</entry><entry morerows="1"> 0.1673</entry><entry morerows="1"> 3.625</entry></row><row><entry morerows="1"> 26</entry><entry morerows="1"> 24.9</entry><entry morerows="1"> 523</entry><entry morerows="1"> 95</entry><entry morerows="1"> 0.184</entry><entry morerows="1"> 3.568</entry></row><row><entry morerows="1"> 27</entry><entry morerows="1"> 25.5</entry><entry morerows="1"> 657</entry><entry morerows="1"> 130</entry><entry morerows="1"> 0.2007</entry><entry morerows="1"> 3.485</entry></row><row><entry morerows="1"> 28</entry><entry morerows="1"> 26.0</entry><entry morerows="1"> 933</entry><entry morerows="1"> 154</entry><entry morerows="1"> 0.1673</entry><entry morerows="1"> 3.431</entry></row><row><entry morerows="1"> 29</entry><entry morerows="1"> 26.4</entry><entry morerows="1"> 1549</entry><entry morerows="1"> 230</entry><entry morerows="1"> 0.1506</entry><entry morerows="1"> 3.380</entry></row><row><entry morerows="1"> 30</entry><entry morerows="1"> 26.8</entry><entry morerows="1"> 419</entry><entry morerows="1"> 83</entry><entry morerows="1"> 0.2007</entry><entry morerows="1"> 3.323</entry></row><row><entry morerows="1"> 31</entry><entry morerows="1"> 27.3</entry><entry morerows="1"> 350</entry><entry morerows="1"> 69</entry><entry morerows="1"> 0.2007</entry><entry morerows="1"> 3.267</entry></row><row><entry morerows="1"> 32</entry><entry morerows="1"> 28.0</entry><entry morerows="1"> 1108</entry><entry morerows="1"> 146</entry><entry morerows="1"> 0.1338</entry><entry morerows="1"> 3.186</entry></row><row><entry morerows="1"> 33</entry><entry morerows="1"> 29.1</entry><entry morerows="1"> 144</entry><entry morerows="1"> 19</entry><entry morerows="1"> 0.1338</entry><entry morerows="1"> 3.066</entry></row></tbody></tgroup></table></tables> | ||
| 地址 | 法国库伯瓦 | ||